{"id":5153,"date":"2020-08-12T11:04:13","date_gmt":"2020-08-12T11:04:13","guid":{"rendered":"https:\/\/uptec.up.pt\/?p=5153"},"modified":"2020-08-12T11:04:13","modified_gmt":"2020-08-12T11:04:13","slug":"startup-identifica-substancias-provenientes-da-ra-com-potencial-para-agir-contra-covid-19","status":"publish","type":"post","link":"https:\/\/uptec.fera.miewstudio.com\/pt-pt\/startup-identifica-substancias-provenientes-da-ra-com-potencial-para-agir-contra-covid-19\/","title":{"rendered":"Startup identifica subst\u00e2ncias provenientes da r\u00e3 com potencial para agir contra COVID-19"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row][vc_column width=&#8221;1\/1&#8243;][vc_column_text alpha-anim&#8221;]A <strong><a href=\"http:\/\/www.bioprospectum.com\/\">Bio<em>prospectum<\/em><\/a><\/strong>, empresa incubada na <strong><a href=\"https:\/\/uptec.fera.miewstudio.com\">UPTEC<\/a> \u2014 Parque de Ci\u00eancia e Tecnologia da U. Porto<\/strong>, identificou duas subst\u00e2ncias com potencial atividade antiviral e que podem <strong>neutralizar partes estruturais do SARS-CoV<\/strong>, atrav\u00e9s de qu\u00edmica computacional. As primeiras mol\u00e9culas ser\u00e3o testadas <em>in vitro<\/em> \u2013 em cultura de c\u00e9lulas \u2013 ainda durante o m\u00eas de agosto.[\/vc_column_text][\/vc_column][\/vc_row][vc_row unlock_row_content=&#8221;yes&#8221; row_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; el_class=&#8221;margin-top-30&#8243;][vc_column width=&#8221;5\/12&#8243;][vc_single_image media=&#8221;5156&#8243; media_width_percent=&#8221;81&#8243; alignment=&#8221;right&#8221; bottom-t-top&#8221; title=&#8221;Peter Eaton&#8221;][vc_empty_space empty_h=&#8221;5&#8243;][vc_single_image media=&#8221;5161&#8243; media_width_percent=&#8221;81&#8243; alignment=&#8221;right&#8221; bottom-t-top&#8221; title=&#8221;Cristina Soares&#8221;][\/vc_column][vc_column width=&#8221;7\/12&#8243;][vc_column_text alpha-anim&#8221;]A <strong>empresa portuense identificou dois p\u00e9ptidos<\/strong> \u2014 biomol\u00e9culas formadas pela liga\u00e7\u00e3o de dois ou mais amino\u00e1cidos \u2014 provenientes da <strong>r\u00e3-verde ib\u00e9rica, encontrada nos A\u00e7ores<\/strong>, que podem ser usados num antiviral para tratar as infe\u00e7\u00f5es causadas pelo SARS-CoV-2. Os<strong> testes<\/strong> v\u00e3o decorrer em colabora\u00e7\u00e3o com o <strong>iMED \u2013 Instituto de Investiga\u00e7\u00e3o do Medicamento da Faculdade de Farm\u00e1cia da Universidade de Lisboa.<\/strong>[\/vc_column_text][vc_empty_space empty_h=&#8221;2&#8243;][vc_column_text alpha-anim&#8221;]A plataforma <em>in silico,<\/em> desenvolvida pela Bio<em>prospectum<\/em> em parceria com a MI4U, empresa brasileira de intelig\u00eancia artificial\u200e, permite selecionar de uma amostra as subst\u00e2ncias mais apropriadas para um determinado fim \u2014 definido pelo investigador \u2014 e, desta forma, evitar uma an\u00e1lise pormenorizada a cada mol\u00e9cula dessa mesma amostra.[\/vc_column_text][vc_empty_space empty_h=&#8221;2&#8243;][vc_column_text alpha-anim&#8221;]Atrav\u00e9s de uma base de dados molecular, da utiliza\u00e7\u00e3o de qu\u00edmica computacional e bioinform\u00e1tica, a plataforma da Bio<em>prospectum<\/em> consegue analisar de uma forma muito mais r\u00e1pida e eficiente todas as mol\u00e9culas de uma amostra, permitindo ao investigador focar-se apenas nas mol\u00e9culas que podem ser \u00fateis para o estudo. \u201cA<strong> identifica\u00e7\u00e3o de mol\u00e9culas com atividade farmacol\u00f3gica pode demorar anos de trabalho<\/strong>, se for feita com m\u00e9todos cl\u00e1ssicos, o grande diferencial de <strong>aliar a bioprospec\u00e7\u00e3o com intelig\u00eancia\u00a0artificial \u00e9 que os primeiros resultados podem ser gerados em meses.<\/strong>\u201d, afirma Jos\u00e9 Leite, copromotor do projeto.[\/vc_column_text][vc_empty_space empty_h=&#8221;2&#8243;][vc_column_text alpha-anim&#8221;]A Bio<em>prospectum<\/em>\u00a0tem vindo a criar \u2014 e a aumentar \u2014 um banco de mol\u00e9culas da biodiversidade Ibero-Americana, com o objetivo de aumentar a efic\u00e1cia e efici\u00eancia da prospe\u00e7\u00e3o de mol\u00e9culas potencialmente \u00fateis em qualquer amostra.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/1&#8243;][vc_column_text alpha-anim&#8221;]A Bio<em>prospectum<\/em>, spin-off do i3S, tem desenvolvido, ao longo dos \u00faltimos anos, plataformas para a identifica\u00e7\u00e3o de mol\u00e9culas com \u00eanfase em aplica\u00e7\u00f5es antioxidantes, antimicrobianas, anti-inflamat\u00f3rias e anti-cancro. Desta vez, a plataforma da empresa est\u00e1 a identificar mol\u00e9culas que possam ser utilizadas contra a Covid-19.[\/vc_column_text][\/vc_column][\/vc_row]<\/div>","protected":false},"excerpt":{"rendered":"Testes in vitro contra SARS-CoV-2 iniciam j\u00e1 este m\u00eas. 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